Adult Changes in Thought Study

ACT P&P Approved Projects 2022

Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.

Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.

Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.

Information on Projects Approved During 2022
Submission TypeLead Investigator First NameLead Investigator Last NameContact EmailInstitutional AffiliationSubmission TitleKey WordsProject #Affiliated ACT Project/Core or Other Related GrantDate of Approval
Data RequestMoon IlKangmikang@bu.eduBoston University School of MedicineA Genome-Wide Search for Pleiotropy in Cognitive Domains and Brain MRI Measures 246SAG2/28/2022
Data RequestElizabethBlueem27@uw.eduUniversity of WashingtonEnhanced Analysis of APOE, Sex, and Age-at-Onset Effects on the Genomics of Alzheimer’s disease 247SAG3/14/2022
Data RequestCaitlinLatimercaitlinl@uw.eduUniversity of WashingtonNeuropathologic change and cognition in the oldest-old: comparison of the ACT and 90+ Study cohorts 248NP Core4/18/2022
Data RequestCaitlinLatimercaitlinl@uw.eduUniversity of WashingtonLimbic-predominant Age-related TDP-43 Encephalopathy-Neuropathologic Change in ACT 249NP Core4/18/2022
AbstractYinxiangWuwuyx@uw.eduUniversity of WashingtonAnalysis of the 24-Hour Activity Cycle: Associations with cognitive function in the Adult Changes in Thought (ACT) Study N/AACT P1 4/12/2022
Data RequestRobynHonearhonea@kumc.eduUniversity of Kansas School of MedicineDeciphering multi-modal risk factors influencing expression of dementia 250SAG4/14/2022
ManuscriptBoeunKimbonnie16@uw.eduUniversity of WashingtonMediating Role of Walking between Perceived and Objective Walkability and Cognitive Function in Older Adults 209N/A 5/5/2022
Data RequestRebeccaHubbardrhubb@upenn.eduUniversity of PennsylvaniaMethods for integrative analysis of modern data sources to advance understanding of Alzheimer’s Disease 233a2335/5/2022
Data RequestAnnieDoubledaydoubleda@uw.eduUniversity of WashingtonAir pollution exposure and performance-based physical function in the ACT cohort 54bACT AIR5/5/2022
Data RequestChristineMacDonaldcmacd@uw.eduUniversity of WashingtonComparison of Health Demographics and MRI Findings in Aging Studies with Research and Clinical MRI: Implications for Translatability to the Broader Population 115aACT AIR7/30/2022
Data RequestNatHeintzNathaniel.Heintz@rockefeller.eduRockefeller UniversityCell type specific analyses of cognitively-defined AD subgroups  253 7/30/2022
Data RequestRichardShervasherva@bu.eduBoston UniversityGenetics of AD and Related Dementias in African Americans 252SAG6/23/2022
Data RequestEricMorenzemorenz@uw.eduUniversity of WashingtonCausal Inference in Autopsy Data Settings 54cACT AIR9/12/2022
Data RequestLianneSheppardsheppard@uw.eduUniversity of WashingtonModeled Exposure to ultrafine particles and Alzheimer’s Disease Neuropathology at Autopsy in a Community-Based Cohort 258ACT AIR9/1/2022
Data RequestGaryBeechamgbeecham@med.miami.eduUniversity of MiamiGenomics of Neuropathology of AD/RD 259 9/1/2022
Data RequestSarahTomst3144@cumc.columbia.eduColumbia UniversityOccupation type and neuropathological lesions related to Alzheimer’s Disease 263Life Course Core10/6/2022
Data RequestMikael AnneGreenwood-HickmanMikael.anne.greenwood-hickman@kp.orgKPWHRICharacterizing changes in activity, sleep, mental health, and wellbeing before and during the COVID-19 pandemic and exploring predictors of resilience among older adults 264ACT P1 10/6/2022
ManuscriptYinxiangWuwuyx@uw.eduUniversity of WashingtonAnalysis of the 24-Hour Activity Cycle: An illustration examining the association with cognitive function-in the Adult Changes in Thought (ACT) Study  265ACT P1 10/6/2022
Data RequestElizaMillerecm2137@cumc.columbia.eduColumbia UniversityAdverse Pregnancy Outcomes and Risk of Clinical Dementia in Women in the ACT Study 267Life Course Core10/6/2022
Data RequestEdLeinEdL@alleninstitute.orgAllen Institute for Brain ScienceCohort Data  245Allen U19 SEA-AD10/24/2022
Data RequestEdLeinEdL@alleninstitute.orgAllen Institute for Brain ScienceExpert Determination 245Allen U19 SEA-AD10/24/2022
Data RequestEdLeinEdL@alleninstitute.orgAllen Institute for Brain ScienceNIAGADS 245Allen U19 SEA-AD10/24/2022
Data RequestLoetCoenencoenen@bprc.nlBiomedical Primate Research CentreLinking the Aging Brain Transcriptome to Aging Blood Plasma 257 11/3/2022
Data RequestSarahTomst3144@cumc.columbia.eduColumbia University  266Life Course Core11/3/2022
ManuscriptChristine Mac Donaldcmacd@uw.eduUniversity of WashingtonComparison of brain imaging and physical health between research and clinical neuroimaging and non-imaged cohorts of aging 115a115 (AIR ACT)11/3/2022
Data RequestHarrisonReederhreeder@mgh.harvard.eduMassachusetts General HospitalAccelerated failure time and semi-competing risks survival models for Alzheimer’s research (Aim 1) 269 11/3/2022
Data RequestHarrisonReederhreeder@mgh.harvard.eduMassachusetts General HospitalAccelerated failure time and semi-competing risks survival models for Alzheimer’s research (Aim 2) 27226911/3/2022
Data RequestHarrisonReederhreeder@mgh.harvard.eduMassachusetts General HospitalAccelerated failure time and semi-competing risks survival models for Alzheimer’s research (Aim 3) 27326911/3/2022
Data RequestHarrisonReederhreeder@mgh.harvard.eduMassachusetts General HospitalAccelerated failure time and semi-competing risks survival models for Alzheimer’s research (Aim 4) 27426911/3/2022
Data RequestLauraGibbonsgibbonsl@uw.eduUniversity of WashingtonTransportability of autopsy findings to other populations 232 12/2/2022
ManuscriptEmmaNicholstvos@uw.eduInstitute for Health Metrics and EvaluationThe prevalence, correlation, and co-occurrence of neuropathology in old-age: harmonisation of 12 measures across six community-based autopsy studies of dementia 224 12/1/2022
AbstractDoriRosenbergDori.E.Rosenberg@kp.orgKPWHRIAssociations between profiles of the 24-hour activity cycle in relation to cognitive function in older adults 265 ACT P112/1/2022
ManuscriptLauraGibbonsgibbonsl@uw.eduUniversity of WashingtonAssociation of Traumatic Brain Injury with Late Life Neuropathological Outcomes in a Community-Based Cohort 170 12/1/2022
AbstractMikael AnneGreenwood-HickmanMikael.anne.greenwood-hickman@kp.orgKPWHRIPre-pandemic Sleep and Activity Behaviors and Associated Change in Depressive Symptoms during the COVID-19 Pandemic 264 12/6/2022
AbstractSarahTomst3144@cumc.columbia.eduColumbia University Number of Children and Risk of Dementia 220 12/13/2022