ACT P&P Approved Projects 2023
Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.
Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.
Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.
| Submission Type | Lead Investigator First Name | Lead Investigator Last Name | Contact Email | Institutional Affiliation | Submission Title | Key Words | Project # | Affiliated ACT Project/Core or Other Related Grant | Date of Approval |
|---|---|---|---|---|---|---|---|---|---|
| Data Request | Lincoln | Shade | Lincoln.shade@uky.edu | University of Kentucky | Genome-Wide Association Study of Neuropathological Endophenotypes | 235 | 1/5/2023 | ||
| Manuscript | Christiane | Reitz | cr2101@cumc.columbia.edu | Columbia University | The Early-Onset Alzheimer's Disease Whole-genome Sequencing Project: study design and methodology | 219 | 1/5/2023 | ||
| Data Request | Evan | Grandoit | evan.grandoit@u.northwestern.edu | Northwestern University | Analyses of CERAD word lists with different administration protocols | 271 | 2/2/2023 | ||
| Abstract | Cecelia | Lee | leecs2@uw.edu | University of Washington | Analysis of prospective data from the Eye Adult Changes in Thought study | 124a | EYE ACT | 2/2/2023 | |
| Manuscript | Mo-Kyung | Sin | sinm@seattleu.edu | Seattle University | Relationship between cerebral microinfarcts and dementia by gender among older adults | 204 | 2/2/2023 | ||
| Data Request | Shelly | Gray | slgray@uw.edu | University of Washington | Adult Changes in Thought (ACT) U19 Project 3: Translational Pharmacoepidemiology - Data Only (Aim 2A) | 278 | ACT P3 (Aim 2A) | 2/2/2023 | |
| Data Request | Shelly | Gray | slgray@uw.edu | University of Washington | Adult Changes in Thought (ACT) U19 Project 3: Translational Pharmacoepidemiology - Data Only (Aim 2B) | 279 | ACT P3 (Aim 2B) | 2/2/2023 | |
| Abstract | Annie | Doubleday | doubleda@uw.edu | University of Washington | Ultrafine Particle Exposure and Physical Performance in the Adult Changes in Thought Cohort | 54b | 54b; AIR ACT | 1/30/2023 | |
| Manuscript | Boeun | Kim | bonnie16@uw.edu | University of Washington | Association of Perceived Neighborhood Environments with Cognitive Function in Older Adults | 209 | 2/2/2023 | ||
| Abstract | Magali | Blanco | magali@uw.edu | University of Washington | Association of long-term exposure to ultrafine particles, nitrogen dioxide, and black carbon with dementia incidence in the Adult Changes in Thought cohort | 210 | 1/30/2023 | ||
| Abstract | Paul | Crane | pcrane@uw.edu | University of Washington | The Adult Changes in Thought (ACT) Medical Abstraction Project: A resource for research on the aging brain and Alzheimer's disease and related dementias | 289 | Chart abstraction working group | 1/30/2023 | |
| Abstract | Sagnik | Sinha | University of Washington | Development and assessment of a composite score for overall brain pathology in the Adult Changes in Thought (ACT) autopsy cohort | N/a | Neuropath core data request -no P&P proposal or tracking number | 1/30/2023 | ||
| Abstract | Seo-Eun | Choi | University of Washington | Associations between gray and white matter volumes from ex vivo imaging and Alzheimer's Diseases Neuropathologic Change Score in the ACT autopsy cohort | N/a | Neuropath core data request -no P&P proposal or tracking number | 1/31/2023 | ||
| Data Request | Paul | Crane | pcrane@uw.edu | University of Washington | Implications of choice of timescale in analyses of cognitive decline | 277 | 2/21/2023 | ||
| Data Request | Shelly | Gray | slgray@uw.edu | University of Washington | Association between anticholinergic use and neuroimaging outcomes in ACT participants receiving clinical scans | 280 | 3/2/2023 | ||
| Data Request | Aaron | Seitz | a.seitz@northeastern.edu | Northeastern University | Prep to research for ACT HEAR | 282 | 3/2/2023 | ||
| Manuscript | Mo-Kyung | Sin | sinm@seattleu.edu | Seattle University | Relationships between cerebral vasculopathies and microinfarcts in community-based older adults | 204 | 4/6/2023 | ||
| Abstract | Kristen | Dams-O'Connor | Kristen.dams-oconnor@mountsinai.org | Icahn School of Medicine at Mount Sinai | Clinical Phenotypes of Dementia in Older Adults With and Without a TBI | 170 | 3/16/2023 | ||
| Data Request | Subhabrata "Joey" | Mukherjee | smukherj@uw.edu | University of Washington | Genome-Wide Association Study of brain pathology score | 283 | 4/6/2023 | ||
| Data Request | Eliza | Miller | ecm2137@cumc.columbia.edu | Columbia University | Association of Adverse Pregnancy Outcomes and Cognitive Decline in Women in the Adult Changes in Thought Study | 284 | 267 | 4/6/2023 | |
| Abstract | Janelle | Taylor | University of Toronto | Clinical Encounters with Difficult Transitions: Reading Dementia Care from Chart Notes | 140 | ACT P2 | 3/31/2023 | ||
| Manuscript | Edo | Richard | Edo.richard@radboudumc.nl | Radboud University Medical Centre | Year-by-year blood pressure variability from midlife to death and lifetime dementia risk- a longitudinal cohort study | 163a | 5/4/2023 | ||
| Manuscript | Mikael Anne | Greenwood-Hickman | Mikael.anne.greenwood-hickman@kp.org | KPWHRI | Understanding resilience: Lifestyle-based behavioral predictors of mental health and well-being in community-dwelling older adults during the COVID-19 pandemic | 264 | ACT P1 | 5/4/2023 | |
| Abstract | Janelle | Taylor | janelle.taylor@utoronto.ca | University of Toronto | Housing Concerns and Trajectories of Kinless Older Adults with Dementia | 140 | ACT p2 | 4/24/2023 | |
| Manuscript | Donovan | Maust | maustd@umich.edu | University of Michigan | "Preventable hospitalizations" in older adults with dementia: Are they really preventable? | potentially preventable hospitalization, ambulatory care sensitive condition, congestive heart failure, pneumonia, dementia, aged | 131 | 7/13/2023 | |
| Manuscript | Kelly | Chang | kchang4@uw.edu | University of Washington | Diffusion MRI sheds light on FLAIR white matter hyperintensities in an aging cohort | diffusional kurtosis imaging, free-water diffusion tensorimaging, FLAIR, unsupervised learning, principal component analysis, tractography | 288 | ACT Imaging | 7/13/2023 |
| Data Request | Nicole Gatto | Gatto | nicole.m.gatto@kp.org | KPWHRI | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer's disease and related dementias | chart abstraction, historical data, medical conditions | 289 | ACT Medical Records WG | 7/13/2023 |
| Data Request | Mikael Anne | Greenwood-Hickman | Mikael.anne.greenwood-hickman@kp.org | KPWHRI | ACT-Activity Monitor Sub-Study - Sleep, diagnosis and medications | 290 | ACT P1 | 6/22/2023 | |
| Data Request | Mikael Anne | Greenwood-Hickman | Mikael.anne.greenwood-hickman@kp.org | KPWHRI | ACT-Activity Monitor Sub-Study - dataset development | 291 | ACT P1 | 6/22/2023 | |
| Data Request | Dori | Rosenberg | Dori.E.Rosenberg@kp.org | KPWHRI | Cognitive function trajectories as predictors of physical activity, sedentary time, and sleep | cognition, trajectories, physical activity | 294 | ACT P1 | 7/13/2023 |
| Abstract | Sagnik | Sinha | University of Washington | Development and assessment of a composite score for overall brain pathology in autopsy cohorts | AAIC_2023 | Neuropath Core | 7/13/2023 | ||
| Abstract | Tiara | Schwarze-Taufiq | University of Washington | Differential Effects of Anticholinergic Medications in a Human Neuronal Model of AD | AAIC_2023 | ACT P3 | 7/13/2023 | ||
| Data Request | Pascal | Geldsetzer | pgeldsetzer@stanford.edu | Stanford University | Association of herpes zoster episodes and cognitive decline in the Adult Changes in Thought (ACT) Study | Herpes zoster, shingles, dementia, cognitive decline | 296 | 9/12/2023 | |
| Data Request | Cecilia | Lee | leecs2@uw.edu | University of Washington | Association between AMD severity score and risk of dementia | EyeACT, AMD, dementia | 297 | EYE ACT | 9/12/2023 |
| Data Request | Cecilia | Lee | leecs2@uw.edu | University of Washington | Eye Adult Changes in Thought (Eye ACT) study - setting and report on the inaugural cohort | EyeACT, cohort, design | 299 | EYE ACT | 9/12/2023 |
| Data Request | Cecilia | Lee | leecs2@uw.edu | University of Washington | Feature-based Grading System of Age-related Macular Degeneration Severity using Clinical Electronic Medical Records Data | Eye ACT, Age-related macular degeneration, severity score, AREDS, anti-VEGF | 300 | EYE ACT | 9/12/2023 |
| Manuscript | Janelle | Taylor | janelle.taylor@utoronto.ca | University of Toronto | The Clock-Drawing Test: Reading Temporalities of Dementia from Clinical Chart Notes | n/a | 140 | ACT P2 | 10/5/2023 |
| Manuscript | Annie | Doubleday | doubleda@uw.edu | University of Washington | Traffic-Related Air Pollutant Exposure and Physical Performance in the Adult Changes in Thought Cohort | n/a | 54b | AIR ACT | 9/29/2023 |
| Abstract | Gail | Li | gli@uw.edu | University of Washington | Association between air pollution and Lewy-body pathology - a large autopsy study | n/a | 54 | AIR ACT | 9/26/2023 |
| Data Request | Nicole | Gatto | nicole.m.gatto@kp.org | KPWHRI | Omega-3 fatty acids from fish oil supplementation and cognitive decline, incident Alzheimer's disease and dementia in the Adult Changes in Thought (ACT) Study | omega-3 fatty acids, fish oil supplements, cognitive decline, Alzheimer's disease, dementia | 302 | 10/5/2023 | |
| Data Request | Cecilia | Lee | leecs2@uw.edu | University of Washington | Glaucoma Medications and Dementia Risk | Glaucoma, topical medications, dementia | 298 | EYE ACT | 10/26/2023 |
| Manuscript | Dori | Rosenberg | Dori.E.Rosenberg@kp.org | KPWHRI | Historic Cognitive Function Trajectories as Predictors of Sedentary Behavior and Physical Activity in Older Adults test | 294 | ACT P1 | 11/2/2023 | |
| Data Request | Gwen | Lapham | Gwen.t.lapham@kp.org | KPWHRI | Cannabis use among ACT cohort participants 2016 - present | 307 | 11/2/2023 | ||
| Data Request | Nicole | Gatto | nicole.m.gatto@kp.org | KPWHRI | Efforts to increase the racial and ethnic and socioeconomic diversity of the Adult Changes in Thought Cohort | diversity, race and ethnicity, socioeconomic status, representativeness, cohort | 309 | ACT Sample Diversity WG | 11/2/2023 |
| Abstract | Cecilia | Lee | leecs2@uw.edu | University of Washington | Eye Adult Changes in Thought (Eye ACT) study: Settings and report on the inaugural cohort | 299 | EYE ACT | 11/21/2023 | |
| Abstract | Kelly | Chang | kchang4@uw.edu | University of Washington | Advanced diffusion modeling classifies FLAIR white matter hyperintensity types in an aging cohort | 288 | ACT Imaging | 11/15/2023 | |
| Data Request | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Marital status and sedentary behaviors in the Adult Changes in Thought Study | Marital status, sedentary behaviors, social determinants of health | 314 | ACT P1 | 12/5/2023 |
| Abstract | Kathryn | Scherpelz | kpsch@uw.edu | University of Washington | Association for Research in Vision and Ophthalmology | 315 | EYE ACT | 12/20/2023 | |
| Manuscript | Laura | Gibbons | gibbonsl@uw.edu | University of Washington | Extending community-based research on older adults to the Seattle area population | bias, epidemiological research design, eye diseases, dementia, generalizability, transportability, integrated health-care delivery systems, prevalence | 232 | 12/20/2023 | |
| Data Request | Mo-Kyung | Sin | sinm@seattleu.edu | Seattle University | Relationship between CAA and dementia | 251 | 12/21/2023 | ||
| Abstract | Nicole | Gatto | nicole.m.gatto@kp.org | KPWHRI | Efforts to increase the racial and ethnic and socioeconomic diversity of the Adult Changes in Thought Cohort | diversity, race and ethnicity, socioeconomic status, representativeness, cohort | 309 | ACT Sample Diversity WG | 12/22/2023 |