Adult Changes in Thought Study

ACT P&P Approved Projects 2025

Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.

Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.

Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.

Caption 20250421-0918
Submission TypeLead Investigator First NameLead Investigator Last NameContact EmailInstitutional AffiliationSubmission TitleKey WordsProject #Affiliated ACT Project/Core or Other Related GrantDate of Approval
ManuscriptMikael AnneGreenwood-Hickmanmikael.anne.greenwood-hickman@kp.orgKPWHRIAssociations Between 10-year Physical Performance and Activities of Daily Living Trajectories with Physical Behaviors in Older Adultsphysical activity, sedentary behavior, sitting, sleep319 1/8/2025
Data RequestSarahTomst3144@cumc.columbia.eduColumbia UniversityInternet use and cognition in the Adult Changes in Thought Studyinternet use, cognition, older adults360ACT Life Course Core1/8/2025
Data RequestKatrinaBazemorebazemork@pennmedicine.upenn.eduUniversity of PennsylvaniaPolygenic Risk Scores for Probable Alzheimer’s Disease (AD)- Related Dementias Genome-Wide Association Studies by Proxy (GWAX)AD PRS Informed GWAX361 5/1/2025
AbstractWillaBrenowitzWilla.D.Brenowitz@kpchr.orgKaiser Permanente Center for Health ResearchAssociations of hearing loss and hearing aid use with brain pathologies at autopsy in a community-based cohort 241 1/28/2025
AbstractLilyShapiroLily.X.Shapiro@kp.orgKPWHRIDementia Caregiving and the Limits of Biomedicine: Navigating Bureaucracy and Developing Expertise 363ACT P22/13/2025
AbstractLilyShapiroLily.X.Shapiro@kp.orgKPWHRIUsing qualitative analysis of secure messages to explore the experience of patients with dementia and their caregivers 364ACT P22/13/2025
Data RequestShellyGrayslgray@uw.eduUniversity of WashingtonCNS-active medications and association with sedentary time and physical activity in older adultsCNS-active medications, sedentary time, physical activity365ACT P13/6/2025
AbstractPattiCurlpcurl@uw.eduUniversity of WashingtonCognitively-defined AD dementia subgroups have different MRI white matter hyperintensity distribution in a community-based cohortAAIC 2025343ACT P23/6/2025
Data RequestMagaliBlancomagali@uw.eduUniversity of WashingtonHeterogeneity in the effect of APOE on dementia riskAPOE, dementia, effect modifiers, causal inference336 3/6/2025
Data RequestHelenSuhHelen.suh@tufts.eduTufts UniversityAirborne metals, neurodegeneration, and dementia in the Adult Changes in Thought studyair pollution, cognitive trajectories, dementia3663163/6/2025
Data RequestIsaacCraneicrane@uchicago.eduUniversity of ChicagoAssociations between accelerated brain aging, multiple MRI modalities, and AD-related and vascular disease related genetic risk scoresaccelerated brain aging (structural MRI), functional connectivity, genetic risk scores348 4/3/2025
Data RequestArielRokemarokem@uw.eduUniversity of WashingtonAssociations between blood glucose levels, white matter tissue properties, and cognitive profiles in agingWhite matter, Glucose, Aging356ACT P2: Cognitively defined subgroups5/1/2025
AbstractCaitlinLatimercaitlinl@uw.eduUniversity of WashingtonCognitively defined AD dementia subgroups have different neuropathology findings in a community-based autopsy cohortAAIC 2025369NP Core4/3/2025
AbstractJoshuaRussell University of WashingtonDevelopment of an automated pipeline for systematically quantifying brain arteriolosclerosis from postmortem tissueAAIC 2025370 4/3/2025
ManuscriptShellyGrayslgray@uw.eduUniversity of WashingtonCumulative anticholinergic exposure and change in gait speed and grip strength in older adultsAged, gait speed, hand strength, anticholinergic medications218Internal UW funds (218)4/3/2025
AbstractSarahTomst3144@cumc.columbia.eduColumbia UniversityInternet Use and Cognition in Older AdultsAPHA360LC Core 5/1/2025
Data RequestChloeKrakauerchloe.a.krakauer@kp.orgKPWHRILiving Arrangement and Cognition: Approaches to Analyzing Interval-Censored Data in ACTLiving arrangement, cognition, interval-censored374ACT Life Course Core5/1/2025
Data RequestMichelleCauncaMichelle.Caunca@ucsf.eduUCSFAssociations between Individual-Level Property Value and Cognitive Functionsocial epidemiology, cognition368ACT Life Course Core5/1/2025