ACT P&P Approved Projects 2024
Once receiving approval by the ACT P&P Committee, information about scholarly works (manuscripts, abstracts, etc.) and data requests leading to scholarly works is shared to facilitate collaboration on active ongoing projects and to reduce potential duplication of research on the ACT cohort. Approved projects are catalogued in searchable tables by year.
Approved data requests and manuscript proposals initiate the formation of writing groups of co-authors. Interested researchers may nominate themselves or a qualified colleague to participate in a writing group by contacting the lead directly. Writing group nominations should occur within the one month following P&P approval.
Approved final draft manuscripts and abstracts are shared for informational purposes. Researchers who are interested in working with ACT data can locate research in the process of being submitted for publication. Once published, manuscripts and abstracts may be found in the ACT Publication Database.
| Submission Type | Lead Investigator First Name | Lead Investigator Last Name | Contact Email | Institutional Affiliation | Submission Title | Key Words | Project # | Affiliated ACT Project/Core or Other Related Grant | Final Decision | Date of resolution |
|---|---|---|---|---|---|---|---|---|---|---|
| Manuscript | Eliza | Miller | ecm2137@cumc.columbia.edu | Columbia University | Adverse pregnancy outcomes and cognitive change in older women | Cognition; Cognitive decline; Pregnancy; Maternal; Hypertensive disorders of pregnancy; Preeclampsia; Preterm birth; Adverse pregnancy outcomes | 267 | Life Course Core | Approve | 7/11/2024 |
| Manuscript | Nicole | Gatto | nicole.m.gatto@kp.org | KPWHRI | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer’s disease and related dementias | chart abstraction, historical data, medical conditions | 289 | ACT Medical Records WG | Approve | 7/11/2024 |
| Abstract | Cecilia | Lee | leecs2@uw.edu | University of Washington | Eye Adult Changes in Thought (Eye ACT) study: Settings and report on the inaugural cohort | 299 | EYE ACT | Approved | 1/5/2024 | |
| Abstract | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Adverse Pregnancy Outcomes and Risk of Clinical Dementia in Women in the ACT Study | 267 | Life Course Core | Approved | 1/5/2024 | |
| Manuscript | Magali | Blanco | magali@uw.edu | University of Washington | Traffic-related air pollution and dementia incidence in the Adult Changes in Thought Study | diversity, race and ethnicity, socioeconomic status, representativeness, cohort | 210 | AIR ACT | Approved | 1/8/2024 |
| Manuscript | Magali | Blanco | magali@uw.edu | University of Washington | Impact of Stationary Mobile Monitoring Design on Epidemiologic Inference – A Case Study of Ultrafine Particles and Cognitive Function | 210 | AIR ACT | Approved | 1/9/2024 | |
| Manuscript | Paul | Crane | pcrane@uw.edu | University of Washington | Implications of choice of timescale in analyses of cognitive decline | 277 | Approved | 1/9/2024 | ||
| Manuscript | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Number of children and risk of dementia | Dementia, Cognitive aging, Risk factors in epidemiology, Sex, Gender, Parity | 220 | Approved | 1/12/2024 | |
| Manuscript | Ed | Lein | edl@alleninstitute.org | Allen Institute for Brain Science | Integrated multimodal cell atlas of Alzheimer’s disease | 245 | Approved | 1/23/2024 | ||
| Abstract | Shelly | Gray | slgray@uw.edu | University of Washington | Association Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden | MRI, risk factor, vascular disease | 280 | ACT Neuroimaging Core | Approved | 1/30/2024 |
| Data Request | Norma | Coe | nbcor@pennmedicine.upenn.edu | University of Pennsylvania | Incremental Utilization and Costs of Dementia: Variation by Type | dementia, Alzheimer’s disease, health care utilization, Medicare, aging | 317 | ACT P2 | Approved | 1/30/2024 |
| Manuscript | Cecilia | Lee | leesc2@uw.edu | University of Washington | Eye Adult Changes in Thought (Eye ACT) study – setting and report on the inaugural cohort | Alzheimer’s disease, Adult Changes in Thought (ACT), Eye Adult Changes in Thought (Eye ACT), Ophthalmology, Prospective study, Visual acuity, Contrast sensitivity, Age-related macular degeneration, Cognitive Abilities Screening Instrument (CASI) score, Optical coherence measurement | 299 | EYE ACT | Approved | 1/30/2024 |
| Manuscript | Mikael Anne | Greenwood-Hickman | Rod.L.Walker@kp.org | KPWHRI | Current and historic patterns of chronic disease burden are associated with physical activity and sedentary behavior in older adults: an observational study | multimorbidity, Charlson Comorbidity Index, accelerometer, sedentary behavior, moderate-to-vigorous physical activity (MVPA) | 318 | ACT P1 | Approved | 1/30/2024 |
| Abstract | Norma | Coe | nbcor@pennmedicine.upenn.edu | University of Pennsylvania | Health care utilization and cost differences across cognitively-defined Alzheimer’s disease subgroups | 317 | ACT P2 | Approved | 1/30/2024 | |
| Abstract | Janelle | Taylor | janelle.taylor@utoronto.ca | University of Toronto | Housing Concerns and Trajectories of Kinless Older Adults with Dementia | 140 | ACT P2 | Approved | 1/30/2024 | |
| Abstract | Loet | Coenen | coenen@bprc.nl | Biomedical Primate Research Centre | Multiomic Analyses of Plasma Proteomic Biomarkers of Dementia Suggests a Divergent Brain Aging Trajectory | 257 | Approved | 2/22/2024 | ||
| Abstract | Lily | Shapiro | Lily.X.Shapiro@kp.org | KPWHRI | Using Natural Language Processing to identify text for qualitative research into the lived experience of people with dementia | 320 | ACT P2 | Approved | 2/26/2024 | |
| Data Request | Mikael Anne | Greenwood-Hickman | smccurry@uw.edu | KPWHRI | Independent Associations between Historical Objective Physical Function and Self-Reported Activities of Daily Living over 10-years and 24-hour Activity Behaviors | physical activity, sleep, physical function | 319 | ACT P1 | Approved | 3/7/2024 |
| Data Request | Helen | Suh | Helen.suh@tufts.edu | Tufts University | Airborne metals, neurodegeneration, and dementia in the Adult Changes in Thought study | airborne metals and dementia incidence | 316 | Approved | 3/7/2024 | |
| Data Request | Nolan | Cole | nolan.x.cole@kp.org | KPWHRI/University of Washington | A SIMEX Approach to Address Misclassification in Compositional Data | physical activity, compositional data, measurement error | 321 | ACT P1 | Approved | 3/7/2024 |
| Manuscript | Rebecca | Hubbard | rhubb@upenn.edu | University of Pennsylvania | Integrating Misclassified EHR Outcomes with Validated Outcomes from a Non-probability Sample | Electronic health records, Data integration, Measurement Error, Selection bias, Alzheimer’s disease | 233a | 233 | Approved | 3/7/2024 |
| Abstract | Dori | Rosenberg | Dori.E.Rosenberg@kp.org | KPWHRI | Physical behavior and social determinants research in the Adult Changes in Thought (ACT) cohort study: analytic examples and opportunities for collaboration | 322 | ACT P1 | Approved | 3/7/2024 | |
| Manuscript | Mo-Kyung | Sin | sinm@seattleu.edu | Seattle University | Association of Cerebral Amyloid Angiopathy Prevalence and Severity and Dementia among a Community-based Autopsy Cohort (aim 3) | APOE e4, cerebral amyloid angiopathy, dementia | 251 | Approved | 3/26/2024 | |
| Data Request | Cecilia | Lee | leesc2@uw.edu | University of Washington | Systemic risk factors of glaucoma | Glaucoma, frailty | 323 | EYE ACT | Approved | 3/26/2024 |
| Abstract | Lily | Shapiro | lily.x.shapiro@kp.org | KPWHRI | Imagining Care: Provider reflections on ideal care for people with dementia | 324 | ACT P2 | Approved | 3/26/2024 | |
| Abstract | Dori | Rosenberg | dori.e.rosenberg@kp.org | KPWHRI | Associations between trajectories of cognitive function and physical activity, sedentary time, and sleep in older adults | cognition, trajectories, physical activity | 294 | ACT P1 | Approved | 3/29/2024 |
| Manuscript | Erik | Carlson | esc1@uw.edu | University of Washington | Morphological and Synaptic Integrity of the Cerebellum Correlates with Cognitive Function and Is Affected in Alzheimer’s Disease | Alzheimer’s Disease, Cerebellum, Cognition, Dementia, Atrophy, Posterior Fossa Contents, Inferior Olive, Cerebellar Cortex, Pontine Nuclei, Neuropathology, Granule Cells, Cerebellar Glomerulus, Synapse Loss, Neurodegeneration | 325 | ACT Neuropath Core | Approved | 4/8/2024 |
| Data Request | Lindsay | White | lindsay.white@pennmedicine.upenn.edu | University of Pennsylvania | The effect of retirement on cognition and risk of dementia | dementia, cognitive functioning, retirement | 326 | ACT Life Course Core | Approved | 4/15/2024 |
| Manuscript | Cecilia | Lee | leecs2@uw.edu | University of Washington | Associations between Dementia and Exposure to Topical Glaucoma Medications | Alzheimer’s disease, Adult Changes in Thought (ACT), Eye Adult Changes in Thought (Eye ACT), Ophthalmology, Prospective study, Visual acuity, Contrast sensitivity, glaucoma, Cognitive Abilities Screening Instrument (CASI) score, Optical coherence measurement | 298 | EYE ACT | Approved | 4/15/2024 |
| Data Request | Sarah | Tom | st3144@cumc.columbia.edu | Columbia University | Understanding Functional and Quality Aspects of Social Connection in the Relationship between Living Arrangement and Cognition | Living arrangement, social connection, cognition | 328 | ACT Life Course Core | Approved | 4/24/2024 |
| Manuscript | Lincoln | Shade | lincoln.shade@uky.edu | University of Kentucky | Genome-wide association study of multiple neuropathology endophenotypes identifies novel risk loci and provides insights into genetic risk of dementia | 235 | Approved | 4/26/2024 | ||
| Data Request | Kelly | Chang | kchang4@uw.edu | University of Washington | Free water elimination improves diffusion MRI-based tractometry | Free-water elimination, tractometry, diffusion, white matter hyperintensity | 330 | ACT Neuroimaging Core | Approved | 6/4/2024 |
| Data Request | Laura | Gibbons | gibbonsl@uw.edu | University of Washington | Traumatic brain injury and quantitative neuropathology at autopsy | traumatic brain injury, neuropathology, tau | 331 | Approved | 6/4/2024 | |
| Manuscript | Shelly | Gray | slgray@uw.edu | University of Washington | Association Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden | MRI, risk factor, vascular disease | 280 | ACT Neuroimaging Core | Approved | 6/18/2024 |
| Data Request | Phoebe | Scollard | phosco@uw.edu | University of Washington | MELODEM Data Workshop on Causal and Oblique Random Forest | Random Forest, Survival analysis, APOE | 332 | Approved | 6/25/2024 |