Adult Changes in Thought Study

Neuropathology Data

Neuropathology Data.png Data Description

Some participants of the Adult Changes in Thought (ACT) Study consent to brain autopsy upon death, generously donating their brain for neuropathological assessment by the ACT Neuropathology Core. After autopsy, complete neuropathological assessments are performed, and data elements derived from those assessments of ACT participant brains are collected and stored. The ACT neuropathology dataset contains measures from approximately 850 ACT participants who died as of the current data freeze date March 5, 2020.

Study Forms

Not applicable. Because these data elements are derived directly from neuropathological assessments performed at autopsy, no forms are used to collect these data from participants.

Key Publications

The following publications provide additional detail on the neuropathology data elements. These may be helpful supporting citations when publishing analyses using these data.

  • Marcum ZA, Keene CD, Larson EB. (2021). Leveraging neuropathological data in pharmacoepidemiology: A promising approach for dementia prevention? Pharmacoepidemiology and Drug Safety, 30(1), 1-3.
  •  Lee CS, Latimer CS, Henriksen JC, Blazes M, Larson EB, Crane PK, Keene CD, Lee AY. (2021). Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain Pathology (Zurich, Switzerland), 31(6), e12974.
  • Postupna N, Rose SE, Gibbons LE, Coleman NM, Hellstern LL, Ritchie K, Wilson AM, Cudaback E, Li X, Melief EJ, Beller AE, Miller JA, Nolan AL, Marshall DA, Walker R, Montine TJ, Larson EB, Crane PK, Ellenbogen RG, Lein ES, Dams-O'Connor K, Keene CD. (2021). The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample. Frontiers in Neurology, 12, 624696.